Endocrine Abstracts

Objective: To study the spectrum of chromosomal anomalies in three cases as related to the phenotypic variability of patients with anomalies of disorder of sexual development.Female 18 years old with secondary amenorrhea, stigmata of Turner’s syndrome, Tanner stage II. Ultrasound showed streak gonads. Hormonal analysis revealed elevated levels of FSH, LH and a low plasma estradiol level. The chromosomal investigation showed gonosomal mosaicism 45,X(...

Objectives: To evaluate the presence and the degree of osteoporosis and osteopenia in a group of patients with established hyperthyroidism from at least six months.Material and methods: This study was based on a quantitative measurement of bone mineral density with and heel ultrasound densitometer (Type Pegassus). Each selected patient was recorded for the weight, height, BMI, age, gender. No patient was previously treated for osteoporosis or osteopenia....

IntroductionHashimoto’s thyroiditis (HT) has been linked to papillary carcinoma of the thyroid, Hurthle cell cancer or even lymphoma. In contrast, there are only a few reports of co-existence of HT with medullary thyroid carcinoma. The link between them is unknown. An overall prevalence of medullary carcinoma of only 0.35% has been reported in HT patients. This prevalence is higher in female rather than male. We present the case of a female patient ...

Introduction: Multiple myeloma (MM) is a lethal hematological malignancy with an incidence of 6.1/100 000 per year. The association of thyroid autoimmune diseases and MM is rare and has not been fully investigated. Also, it is well known that agranulocytosis is a potential lethal adverse reaction of antithyroid treatment.Case report: We present the case of a 59-year-old female patient that presented with symptoms of hyperthyroidism. Objectively: Mild bil...

Background: Pancreatic neuroendocrine neoplasms (NENs) are rare tumors which can sometimes be diagnosed based on symptoms of hormone excess, but, more often, they are asymptomatic, and patients frequently present with metastatic disease. While they can occur in hereditary cancer syndromes such as multiple endocrine neoplasia type 1 (MEN1), von Hippel-Lindau (VHL), or neurofibromatosis (NF1), the majority of pancreatic NENs are sporadicCase report: We rep...

The aim of our study was to investigate de relationship between anthropometric and body composition parameters and thyroid function (measured with TSH and free T4), as well as thyroid volume, in patients with obesity.Methods: This is a cross-sectional study including patients with obesity consecutively referred to our tertiary endocrine center for diverse pathologies. TSH and free T4 was measured in all patients and thyroid ultrasound was performed by an...

Obesity has been associated with a status of subclinical inflammation. Neutrophil to lymphocyte ratio (NRL) is a widely available and inexpensive inflammatory marker which can be reliable in evaluating the inflammatory status occurring in patients with severe obesity The aim of our study was to investigate the association between NLR and anthropometric and body-composition parameters, in a group of patients with obesityPatients and Methods: 737 patients ...

Introduction: Syndrome of inappropriate secretion of thyrotropin (SITSH) is a rare condition characterized by uninhibited serum TSH in the presence of high thyroid hormones, usually caused by TSH secreting adenoma or resistance to thyroid hormones (RTH). Differential diagnosis between the two is often challenging due to their overlapping features.Case report: We present the case of a 50-year-old postmenopausal woman with a history of -myocardial infarcti...

Introduction: Multiple Endocrine Neoplasia Syndrome 2B (MEN 2B) is a very rare genetic disorder which affects the thyroid and the adrenal glands, the development of mucosal neuromas and the general appearance of the patient’s body. Therefore, we can encounter Medullary Thyroid Carcinomas (MTC), adrenal sympathetic paragangliomas (or Pheochromocytomas) and habitus Marfanoid. The disease represents a challenge for every clinician, especially if it occurs in a child.<p c...

Background: Chromogranin A (CgA) belongs to the family of granins, proteins which are an integral part of the secretory granules of neuroendocrine cells in endocrine glands and the diffuse neuroendocrine system. While it has become standard clinical practice to measure serum CgA in neuroendocrine tumors, various other non-endocrine conditions may increase this marker’s concentration and lead to diagnostic problems.Case report: We present the case of...